Structure of PDB 1tsr Chain B Binding Site BS01

Receptor Information
>1tsr Chain B (length=194) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGG
MNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENL
Ligand information
Receptor-Ligand Complex Structure
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PDB1tsr Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R248 R273 C275 A276 R280
Binding residue
(residue number reindexed from 1)		R153 R178 C180 A181 R185
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tsr, PDBe:1tsr, PDBj:1tsr
PDBsum1tsr
PubMed8023157
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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