Structure of PDB 1tlz Chain B Binding Site BS01

Receptor Information
>1tlz Chain B (length=248) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSDWWHQSVNVVGSYHTRFGPQIRNDTYLEYEAFAKKDWFDFYGYADAPV
PLFMEIEPRFSIDKLTNTDLSFGPFKEWYFANNYIYDMGRNKDGRQSTWY
MGLGTDIDTGLPMSLSMNVYAKYQWQNYGAANENEWDGYRFKIKYFVPIT
DLWGGQLSYIGFTNFDWGSDLGDDSGNAINGIKTRTNNSIASSHILALNY
DHWHYSVVARYWHDGGQWNDDAELNFGNGNFNVRSTGWGGYLVVGYNF
Ligand information
Ligand IDURI
InChIInChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChIKeyDRTQHJPVMGBUCF-XVFCMESISA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[CH]1O[CH]([CH](O)[CH]1O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)CO
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
CACTVS 3.341OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
FormulaC9 H12 N2 O6
NameURIDINE
ChEMBLCHEMBL100259
DrugBankDB02745
ZINCZINC000002583633
PDB chain1tlz Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1tlz Crystal structure of the bacterial nucleoside transporter Tsx.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		F27 Y53 D55 F77
Binding residue
(residue number reindexed from 1)		F19 Y45 D47 F53
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005337 nucleoside transmembrane transporter activity
GO:0015288 porin activity
GO:0015471 nucleoside-specific channel forming porin activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0015858 nucleoside transport
GO:0046718 symbiont entry into host cell
GO:0055085 transmembrane transport
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0009279 cell outer membrane
GO:0046930 pore complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tlz, PDBe:1tlz, PDBj:1tlz
PDBsum1tlz
PubMed15272310
UniProtP0A927|TSX_ECOLI Nucleoside-specific channel-forming protein Tsx (Gene Name=tsx)

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