Structure of PDB 1sow Chain B Binding Site BS01

Receptor Information
>1sow Chain B (length=323) Species: 5811 (Toxoplasma gondii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVSRRKKIAMIGSGMIGGTMGYLCVLRELADVVLFDVVTGMPEGKALDD
SQATSIADTNVSVTSANQYEKIAGSDVVIITAGLTKVPGKSDKEWSRNDL
LPFNAKIIREVAQGVKKYCPLAFVIVVTNPLDCMVKCFHEASGLPKNMVC
GMANVLDSARFRRFIADQLEISPRDIQATVIGTHGDHMLPLARYVTVNGF
PLREFIKKGKMTEAKLAEIVERTKKAGGEIVRLLGQGSAYYAPALSAITM
AQAFLKDEKRVLPCSVYCQGEYGLHDMFIGLPAVIGGGGIEQVIELELTH
EEQECFRKSVDDVVELNKSLAAL
Ligand information
Ligand IDOXL
InChIInChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2
InChIKeyMUBZPKHOEPUJKR-UHFFFAOYSA-L
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-]C(=O)C([O-])=O
OpenEye OEToolkits 1.5.0C(=O)(C(=O)[O-])[O-]
FormulaC2 O4
NameOXALATE ION
ChEMBL
DrugBank
ZINC
PDB chain1sow Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1sow Structure of apo and ternary forms of Toxoplasma gondii LDH2
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W107 R109 R171 H195 G236
Binding residue
(residue number reindexed from 1)		W95 R97 R160 H184 G227
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) R109 D168 R171 H195
Catalytic site (residue number reindexed from 1) R97 D157 R160 H184
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1sow, PDBe:1sow, PDBj:1sow
PDBsum1sow
PubMed
UniProtQ27797|LDH_TOXGO L-lactate dehydrogenase

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