Structure of PDB 1sk6 Chain B Binding Site BS01

Receptor Information
>1sk6 Chain B (length=454) Species: 1392 (Bacillus anthracis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGV
ATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITE
HEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYE
FRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYD
LFALAPSLTEIKKQIPQKEWDKVVNTPNEKQKGVTNLLIKYGIERKPDST
KGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFI
INPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEW
TDPITKAKINTIPSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKS
KQIAPEYKNYFQYLKERITNQVQLLLTHQKLLYKQLNFTENETDNFEVFQ
KIID
Ligand information
Ligand IDYB
InChIInChI=1S/Yb/q+3
InChIKeyAWSFICBXMUKWSK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Yb+3]
FormulaYb
NameYTTERBIUM (III) ION
ChEMBL
DrugBank
ZINC
PDB chain1sk6 Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1sk6 Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K346 D491 D493
Binding residue
(residue number reindexed from 1)		K53 D198 D200
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Gene Ontology
Molecular Function
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1sk6, PDBe:1sk6, PDBj:1sk6
PDBsum1sk6
PubMed15131111
UniProtP40136|CYAA_BACAN Calmodulin-sensitive adenylate cyclase (Gene Name=cya)

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