Structure of PDB 1shq Chain B Binding Site BS01

Receptor Information

>1shq Chain B (length=476) Species: 6703 (Pandalus borealis)

EEDKAYWNKDAQDALDKQLGIKLREKQAKNVIFFLGDGMSLSTVTAARIY
KGGLTGKFEREKISWEEFDFAALSKTYNTDKQVTDSAASATAYLTGVKTN
QGVIGLDANTVRTNCSYQLDESLFTYSIAHWFQEAGRSTGVVTSTRVTHA
TPAGTYAHVADRDWENDSDVVHDREDPEICDDIAEQLVFREPGKNFKVIM
GGGRRGFFPEEALDIEDGIPGEREDGKHLITDWLDDKASQGATASYVWNR
DDLLAVDIRNTDYLMGLFSYTHLDTVLTRDAEMDPTLPEMTKVAIEMLTK
DENGFFLLVEGGRIDHMHHANQIRQSLAETLDMEEAVSMALSMTDPEETI
ILVTADHGHTLTITGYADRNTDILDFAGISDLDDRRYTILDYGSGPGYHI
TEDGKRYEPTEEDLKDINFRYASAAPKHSVTHDGTDVGIWVNGPFAHLFT
GVYEENYIPHALAYAACVGTGRTFCD

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1shq Chain B Residue 480

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1shq Ligand-binding and metal-exchange crystallographic studies on shrimp alkaline phosphatase.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): D315 H319 H432
• Binding residue (residue number reindexed from 1): D315 H319 H432
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D37 S86 H149 T151 R162 E310 D315 H316 H319 D356 H357 H432
• Catalytic site (residue number reindexed from 1): D37 S86 H149 T151 R162 E310 D315 H316 H319 D356 H357 H432
• Enzyme Commision number: 3.1.3.1: alkaline phosphatase.

Gene Ontology

Molecular Function

• GO:0004035 alkaline phosphatase activity
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0016311 dephosphorylation

Cellular Component

• GO:0098552 side of membrane

External links

• PDB: RCSB:1shq, PDBe:1shq, PDBj:1shq
• PDBsum: 1shq
• PubMed: 15333925
• UniProt: Q9BHT8