Structure of PDB 1shn Chain B Binding Site BS01

Receptor Information
>1shn Chain B (length=476) Species: 6703 (Pandalus borealis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEDKAYWNKDAQDALDKQLGIKLREKQAKNVIFFLGDGMSLSTVTAARIY
KGGLTGKFEREKISWEEFDFAALSKTYNTDKQVTDSAASATAYLTGVKTN
QGVIGLDANTVRTNCSYQLDESLFTYSIAHWFQEAGRSTGVVTSTRVTHA
TPAGTYAHVADRDWENDSDVVHDREDPEICDDIAEQLVFREPGKNFKVIM
GGGRRGFFPEEALDIEDGIPGEREDGKHLITDWLDDKASQGATASYVWNR
DDLLAVDIRNTDYLMGLFSYTHLDTVLTRDAEMDPTLPEMTKVAIEMLTK
DENGFFLLVEGGRIDHMHHANQIRQSLAETLDMEEAVSMALSMTDPEETI
ILVTADHGHTLTITGYADRNTDILDFAGISDLDDRRYTILDYGSGPGYHI
TEDGKRYEPTEEDLKDINFRYASAAPKHSVTHDGTDVGIWVNGPFAHLFT
GVYEENYIPHALAYAACVGTGRTFCD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1shn Chain B Residue 480 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1shn Ligand-binding and metal-exchange crystallographic studies on shrimp alkaline phosphatase.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		D315 H319 H432
Binding residue
(residue number reindexed from 1)		D315 H319 H432
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D37 S86 H149 T151 R162 E310 D315 H316 H319 D356 H357 H432
Catalytic site (residue number reindexed from 1) D37 S86 H149 T151 R162 E310 D315 H316 H319 D356 H357 H432
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
Gene Ontology
Molecular Function
GO:0004035 alkaline phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1shn, PDBe:1shn, PDBj:1shn
PDBsum1shn
PubMed15333925
UniProtQ9BHT8

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