Structure of PDB 1sfq Chain B Binding Site BS01

Receptor Information
>1sfq Chain B (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
>1sfq Chain A (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB1sfq Molecular dissection of na+ binding to thrombin.
Resolution1.91 Å
Binding residue
(original residue number in PDB)		E23 G25 M26 P28 W29 D116 H119 C122 Y134 K135 R137 N159 K202 N205 R206 W207 Y208
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 D113 H116 C119 Y134 K135 R137 N158 K206 N211 R212 W213 Y214
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1sfq, PDBe:1sfq, PDBj:1sfq
PDBsum1sfq
PubMed15152000
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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