Structure of PDB 1ser Chain B Binding Site BS01

Receptor Information
>1ser Chain B (length=421) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVDLKRLRQEPEVFHRAIREKGVALDLEALLALDREVQELKKRLQEVQTE
RNQVAKRVPKAPPEEKEALIARGKALGEEAKRLEEALREKEARLEALLLQ
VPLPPWPGAPVGGEEANREIKRVGGPPEFSFPPLDHVALMEKNGWWEPRI
SQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFL
GTGHFPAYRDQVWAIAETDLYLTGTAEVVLNALHSGEILPYEALPLRYAG
YAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLE
NAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCS
ALLDWQARRANLRYRDPEGRVRYAYTLNNTALATPRILAMLLENHQLQDG
RVRVPQALIPYMGKEVLEPCG
Ligand information
>1ser Chain T (length=65) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaggugcccgaguggcugaagggagguaggggggccucccucgcggguuc
gaaucccgcccucuc
<<<<..<<<...........>>>....<<<<<<..>>>>>>.<<<<<...
....>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB1ser The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser).
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K542 Q545 Q548 T549 N552 A555 V558 P559 I570 G573 K574 R695 R865 V871
Binding residue
(residue number reindexed from 1)		K42 Q45 Q48 T49 N52 A55 V58 P59 I70 G73 K74 R195 R365 V371
Enzymatic activity
Catalytic site (original residue number in PDB) R756 R771 E845 S848 R886
Catalytic site (residue number reindexed from 1) R256 R271 E345 S348 R386
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0070905 serine binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016260 selenocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1ser, PDBe:1ser, PDBj:1ser
PDBsum1ser
PubMed8128220
UniProtP34945|SYS_THET2 Serine--tRNA ligase (Gene Name=serS)

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