Structure of PDB 1rtl Chain B Binding Site BS01

Receptor Information
>1rtl Chain B (length=153) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTN
VDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLL
SPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVTKAVDFIPVENLET
TMR
Ligand information
>1rtl Chain D (length=16) Species: 3052230 (Hepacivirus hominis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB1rtl Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease
Resolution2.75 Å
Binding residue
(original residue number in PDB)		V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 P88 G90
Binding residue
(residue number reindexed from 1)		V2 G4 E5 V6 I8 V9 S10 R35 T36 I37 P61 G63
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H30 D54 G110 S112
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:1rtl, PDBe:1rtl, PDBj:1rtl
PDBsum1rtl
PubMed14627400
UniProtP26664|POLG_HCV1 Genome polyprotein

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