Structure of PDB 1riw Chain B Binding Site BS01

Receptor Information
>1riw Chain B (length=147) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKET
Ligand information
>1riw Chain A (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB1riw The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin
Resolution2.04 Å
Binding residue
(original residue number in PDB)		E44 G46 M47 P49 W50 D149 H152 P153 C155 Y170 K171 G172 R173
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137
Enzymatic activity
Catalytic site (original residue number in PDB) H79 D135
Catalytic site (residue number reindexed from 1) H43 D99
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1riw, PDBe:1riw, PDBj:1riw
PDBsum1riw
PubMed15137772
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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