Structure of PDB 1rg2 Chain B Binding Site BS01

Receptor Information
>1rg2 Chain B (length=434) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDV
DWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIA
FGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADG
THKSGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGST
PGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADE
SKWLCSEFKESMLTLGSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTA
EKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANL
SKAAWGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFMATFPVPY
DLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
Ligand information
Receptor-Ligand Complex Structure
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PDB1rg2 Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y204 F259 H263 S400 G402 P461 S518 A520 W590
Binding residue
(residue number reindexed from 1)		Y46 F101 H105 S242 G244 P294 S351 A353 W416
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rg2, PDBe:1rg2, PDBj:1rg2
PDBsum1rg2
PubMed14761185
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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