Structure of PDB 1rg1 Chain B Binding Site BS01

Receptor Information
>1rg1 Chain B (length=429) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWL
VKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGT
HHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHK
SGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGR
FQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKW
LCSEFKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQN
WLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAA
WGALEKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFFATFPVPYDLPP
ELYGSKDRPWIWNIPYVKAPDTHGNMWVP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1rg1 Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y204 F259 H263 S400 S403 P461 S518 A520
Binding residue
(residue number reindexed from 1)		Y43 F98 H102 S239 S242 P290 S347 A349
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rg1, PDBe:1rg1, PDBj:1rg1
PDBsum1rg1
PubMed14761185
UniProtQ9NUW8|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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