Structure of PDB 1qr7 Chain B Binding Site BS01

Receptor Information
>1qr7 Chain B (length=338) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVV
IGPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGL
INDPHMDNSFQINDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLADLM
SWGAIGARTTESQVHRELASGLSCPVGFKNGTDGTIKVAIDAINAAGAPH
CFLSVTKWGHSAIVNTSGNGDCHIILRGGKEPNYSAKHVAEVKEGLNKAG
LPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESHLVE
GNQSLLAYGKSITDACIGWEDTDALLRQLANAVKARRG
Ligand information
Ligand IDPB
InChIInChI=1S/Pb/q+2
InChIKeyRVPVRDXYQKGNMQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370[Pb++]
valence
OpenEye OEToolkits 1.7.2[Pb+2]
FormulaPb
NameLEAD (II) ION
ChEMBL
DrugBank
ZINC
PDB chain1qr7 Chain B Residue 351 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1qr7 Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C61 H268 E302 D326
Binding residue
(residue number reindexed from 1)		C54 H261 E295 D314
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1qr7, PDBe:1qr7, PDBj:1qr7
PDBsum1qr7
PubMed10425687
UniProtP0AB91|AROG_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (Gene Name=aroG)

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