Structure of PDB 1q3a Chain B Binding Site BS01

Receptor Information
>1q3a Chain B (length=160) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYE
GEADIMISFAVKEHGDNYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT
EDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD
DVNGIQSLYG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1q3a Chain B Residue 469 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1q3a Crystal structure of the catalytic domain of human matrix metalloproteinase 10.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H217 H221 H227
Binding residue
(residue number reindexed from 1)		H114 H118 H124
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H217 E218 H221 H227
Catalytic site (residue number reindexed from 1) H114 E115 H118 H124
Enzyme Commision number 3.4.24.22: stromelysin 2.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q3a, PDBe:1q3a, PDBj:1q3a
PDBsum1q3a
PubMed15095982
UniProtP09238|MMP10_HUMAN Stromelysin-2 (Gene Name=MMP10)

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