Structure of PDB 1pww Chain B Binding Site BS01

Receptor Information
>1pww Chain B (length=734) Species: 1392 (Bacillus anthracis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAI
GGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEP
VLVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTI
KNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEP
QHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLSRYEKWEKIKQH
YQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSNPLSEKEKEFLKKLKLDIQPYDINQRL
QDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMN
INNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERP
ALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEY
IRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYA
SNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIAEQ
YTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHCFGHAV
DDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFR
LMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1pww The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D647 H654 S655 K656 G657 L658 Y659 V660 P661 K673 G674 V675 L677 H686 H690 L707 Y728 E739
Binding residue
(residue number reindexed from 1)		D605 H612 S613 K614 G615 L616 Y617 V618 P619 K631 G632 V633 L635 H644 H648 L665 Y686 E697
Enzymatic activity
Catalytic site (original residue number in PDB) H686 C687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H644 C645 H648 Y686 E693
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0030430 host cell cytoplasm
GO:0044164 host cell cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1pww, PDBe:1pww, PDBj:1pww
PDBsum1pww
PubMed14718924
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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