Structure of PDB 1pjn Chain B Binding Site BS01

Receptor Information
>1pjn Chain B (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
Ligand information
>1pjn Chain A (length=21) Species: 8355 (Xenopus laevis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RKKRKTEEESPLKDKAKKSKG
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1pjn Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S105 W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 W273 Y277 D280 G281 R315 V321 T322 W357 N361 A364 E396 W399 S406
Binding residue
(residue number reindexed from 1)		S34 W71 N75 S78 G79 T84 Q110 W113 N117 D121 W160 R167 W202 Y206 D209 G210 R244 V250 T251 W286 N290 A293 E325 W328 S335
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1pjn, PDBe:1pjn, PDBj:1pjn
PDBsum1pjn
PubMed12695505
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

[Back to BioLiP]