Structure of PDB 1pgu Chain B Binding Site BS01

Receptor Information
>1pgu Chain B (length=608) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDS
KVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKES
NSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN
SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRT
HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP
VQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ
VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLI
SGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGIT
KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSA
VSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSET
YIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWKPAEEIEEDLVA
TGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACI
KRWNVVLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1pgu Chain A Residue 616 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1pgu The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H328 E330
Binding residue
(residue number reindexed from 1)		H327 E329
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0030042 actin filament depolymerization
GO:0032466 negative regulation of cytokinesis
GO:0051016 barbed-end actin filament capping
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0030479 actin cortical patch
GO:0030864 cortical actin cytoskeleton
GO:0043332 mating projection tip

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1pgu, PDBe:1pgu, PDBj:1pgu
PDBsum1pgu
PubMed12807914
UniProtP46680|AIP1_YEAST Actin-interacting protein 1 (Gene Name=AIP1)

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