Structure of PDB 1peg Chain B Binding Site BS01

Receptor Information
>1peg Chain B (length=256) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECM
YSTCQCLDEMAPKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKD
CPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEE
ADRRRAESTIARRKDVYLFALDKFSDPDSLLEVDGEYMSGPTRFINHSCD
PNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNGTKCLCGTAK
CRGYLW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1peg Structural basis for the product specificity of histone lysine methyltransferases
Resolution2.59 Å
Binding residue
(original residue number in PDB)
Y178 V203 L205 F206 A207 D209 I250 Y283 W318
Binding residue
(residue number reindexed from 1)
Y141 V166 L168 F169 A170 D172 I205 Y238 W256
Enzymatic activity
Catalytic site (original residue number in PDB) Y178 Y283
Catalytic site (residue number reindexed from 1) Y141 Y238
Enzyme Commision number 2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0042054 histone methyltransferase activity
GO:0046872 metal ion binding
GO:0046974 histone H3K9 methyltransferase activity
GO:0140949 histone H3K9 trimethyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:1peg, PDBe:1peg, PDBj:1peg
PDBsum1peg
PubMed12887903
UniProtQ8X225|DIM5_NEUCR Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (Gene Name=dim-5)

[Back to BioLiP]