Structure of PDB 1peg Chain B Binding Site BS01
Receptor Information
>1peg Chain B (length=256) Species:
5141
(Neurospora crassa) [
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LPISIVNREDDAFLNPNFRFIDHSIIGKNVPVADQSFRVGCSCASDEECM
YSTCQCLDEMAPKRFAYYSQGAKKGLLRDRVLQSQEPIYECHQGCACSKD
CPNRVVERGRTVPLQIFRTKDRGWGVKCPVNIKRGQFVDRYLGEIITSEE
ADRRRAESTIARRKDVYLFALDKFSDPDSLLEVDGEYMSGPTRFINHSCD
PNMAIFARVGDHADKHIHDLALFAIKDIPKGTELTFDYVNGTKCLCGTAK
CRGYLW
Ligand information
>1peg Chain Q (length=5) Species:
9606
(Homo sapiens) [
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ARKST
Receptor-Ligand Complex Structure
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PDB
1peg
Structural basis for the product specificity of histone lysine methyltransferases
Resolution
2.59 Å
Binding residue
(original residue number in PDB)
Y178 V203 L205 F206 A207 D209 I250 Y283 W318
Binding residue
(residue number reindexed from 1)
Y141 V166 L168 F169 A170 D172 I205 Y238 W256
Enzymatic activity
Catalytic site (original residue number in PDB)
Y178 Y283
Catalytic site (residue number reindexed from 1)
Y141 Y238
Enzyme Commision number
2.1.1.355
: [histone H3]-lysine(9) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0003690
double-stranded DNA binding
GO:0005515
protein binding
GO:0008168
methyltransferase activity
GO:0008270
zinc ion binding
GO:0042054
histone methyltransferase activity
GO:0046872
metal ion binding
GO:0046974
histone H3K9 methyltransferase activity
GO:0140949
histone H3K9 trimethyltransferase activity
Biological Process
GO:0006338
chromatin remodeling
GO:0032259
methylation
Cellular Component
GO:0005634
nucleus
GO:0005694
chromosome
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1peg
,
PDBe:1peg
,
PDBj:1peg
PDBsum
1peg
PubMed
12887903
UniProt
Q8X225
|DIM5_NEUCR Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (Gene Name=dim-5)
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