Structure of PDB 1p91 Chain B Binding Site BS01

Receptor Information
>1p91 Chain B (length=258) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFSCPLCHQPLSREKNSYICPQRHQFDMAKEGYVNLLPDSAEMMQARRAF
LDAGHYQPLRDAIVAQLRERLDDKATAVLDIGCGEGYYTHAFADALPEIT
TFGLDVSKVAIKAAAKRYPQVTFCVASSHRLPFSDTSMDAIIRIYAPCKA
EELARVVKPGGWVITATPGPRHLMELKGLIYNEVHLHAPHAEQLEGFTLQ
QSAELCYPMRLRGDEAVALLQMTPFAWRAKPEVWQTLAAKEVFDCQTDFN
IHLWQRSY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1p91 Chain B Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1p91 Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C5 C8 H25
Binding residue
(residue number reindexed from 1)		C4 C7 H24
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.187: 23S rRNA (guanine(745)-N(1))-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008989 rRNA (guanine-N1-)-methyltransferase activity
GO:0046872 metal ion binding
GO:0052911 23S rRNA (guanine(745)-N(1))-methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0032259 methylation
GO:0070475 rRNA base methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1p91, PDBe:1p91, PDBj:1p91
PDBsum1p91
PubMed14999102
UniProtP36999|RLMA_ECOLI 23S rRNA (guanine(745)-N(1))-methyltransferase (Gene Name=rlmA)

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