Structure of PDB 1p16 Chain B Binding Site BS01

Receptor Information

>1p16 Chain B (length=377) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MVQLEEREIPVIPGNKLDEEETKELRLMVAELLGRRNTGFPGSQPVSFER
RHLEETLMQKDYFVCEKTDGLRCLLFLINDPDKGEGVFLVTRENDYYFIP
NIHFPLSVNETREKPTYHHGTLLDGELVLENRNVSEPVLRYVIFDALAIH
GKCIIDRPLPKRLGYITENVMKPFDNFKKHNPDIVNSPEFPFKVGFKTML
TSYHADDVLSKMDKLFHASDGLIYTCAETPYVFGTDQTLLKWKPAEENTV
DFQLEFVFNEVQYLDYDAKPNLIKLRVWQGSNVHTDFAKLDLSDDDWERL
KALEQPLQGRIAECRQSTTKKGYWEMLRFRNDKSNGNHISVVEKILVSIK
DGVKEKEVIEWCPKISRAWKKRENDRR

Ligand information

>1p16 Chain C (length=9) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TSPSYSPTS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1p16 Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Y203 H204
Binding residue (residue number reindexed from 1)	Y203 H204

Enzymatic activity

Enzyme Commision number

2.7.7.50: mRNA guanylyltransferase.

Gene Ontology

	Molecular Function
GO:0004484	mRNA guanylyltransferase activity
GO:0005524	ATP binding

	Biological Process
GO:0006370	7-methylguanosine mRNA capping

	Cellular Component
GO:0031533	mRNA capping enzyme complex

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Cellular Component

External links

PDB	RCSB:1p16, PDBe:1p16, PDBj:1p16
PDBsum	1p16
PubMed	12820968
UniProt	P78587\|MCE1_CANAX mRNA-capping enzyme subunit alpha (Gene Name=CGT1)

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