Structure of PDB 1ot5 Chain B Binding Site BS01

Receptor Information
>1ot5 Chain B (length=477) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAA
IVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDYHGTRCAGEIA
AKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCS
WGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNC
NYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHSSD
INGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLE
KNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPT
LYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRGTT
TVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKIKV
KTTENGHRIDFHSWRLKLFGESIDSSK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1ot5 2.4 A Resolution Crystal Structure of the Prototypical Hormone-Processing Protease Kex2 in Complex with an Ala-Lys-Arg Boronic Acid Inhibitor
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D176 H213 S272 W273 G274 P275 D277 A311 G313 N314 D325 S385
Binding residue
(residue number reindexed from 1)		D54 H91 S150 W151 G152 P153 D155 A189 G191 N192 D203 S263
Enzymatic activity
Catalytic site (original residue number in PDB) D175 H213 N314 S385
Catalytic site (residue number reindexed from 1) D53 H91 N192 S263
Enzyme Commision number 3.4.21.61: kexin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1ot5, PDBe:1ot5, PDBj:1ot5
PDBsum1ot5
PubMed12779325
UniProtP13134|KEX2_YEAST Kexin (Gene Name=KEX2)

[Back to BioLiP]