Structure of PDB 1osv Chain B Binding Site BS01

Receptor Information
>1osv Chain B (length=229) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEENFLILTEMAT
SHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPA
GHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILS
PDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRT
FNHHHAEMLMSWRVNDHKFTPLLCEIWDV
Ligand information
Receptor-Ligand Complex Structure
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PDB1osv Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Resolution2.5 Å
Binding residue
(original residue number in PDB)
V296 K300 H310 K318 L461 E464
Binding residue
(residue number reindexed from 1)
V57 K61 H71 K79 L222 E225
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function

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Biological Process
External links
PDB RCSB:1osv, PDBe:1osv, PDBj:1osv
PDBsum1osv
PubMed12718893
UniProtQ62735|NR1H4_RAT Bile acid receptor (Gene Name=Nr1h4)

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