Structure of PDB 1osv Chain B Binding Site BS01
Receptor Information
>1osv Chain B (length=229) Species:
10116
(Rattus norvegicus) [
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AELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEENFLILTEMAT
SHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPA
GHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILS
PDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRT
FNHHHAEMLMSWRVNDHKFTPLLCEIWDV
Ligand information
>1osv Chain D (length=12) Species:
10090
(Mus musculus) [
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ENALLRYLLDKD
Receptor-Ligand Complex Structure
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PDB
1osv
Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
V296 K300 H310 K318 L461 E464
Binding residue
(residue number reindexed from 1)
V57 K61 H71 K79 L222 E225
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0004879
nuclear receptor activity
GO:0032052
bile acid binding
Biological Process
GO:0006355
regulation of DNA-templated transcription
GO:0038183
bile acid signaling pathway
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Molecular Function
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Biological Process
External links
PDB
RCSB:1osv
,
PDBe:1osv
,
PDBj:1osv
PDBsum
1osv
PubMed
12718893
UniProt
Q62735
|NR1H4_RAT Bile acid receptor (Gene Name=Nr1h4)
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