Structure of PDB 1ook Chain B Binding Site BS01

Receptor Information
>1ook Chain B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ook Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H57 Y60A L99 I174 D189 A190 S195 W215 G216
Binding residue
(residue number reindexed from 1)		H43 Y47 L96 I179 D199 A200 S205 W227 G228
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ook, PDBe:1ook, PDBj:1ook
PDBsum1ook
PubMed12855810
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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