Structure of PDB 1ooa Chain B Binding Site BS01

Receptor Information
>1ooa Chain B (length=313) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNY
VGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGVCTVTAGPKDMVVGFANL
GILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEGGGDRQLT
DREKEIIRQAAVQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAI
YDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEE
NGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDL
ETSEPKPFLYYPE
Ligand information
>1ooa Chain D (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauacuugaaacuguaagguuggcguaug
<<<<<....<<<<....>>>>...>>>>>
Receptor-Ligand Complex Structure
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PDB1ooa Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		R54 R56 Y57 C59 E60 P62 S63 H64 T143 K144 K145 K241 A242 P243
Binding residue
(residue number reindexed from 1)		R17 R19 Y20 C22 E23 P25 S26 H27 T106 K107 K108 K204 A205 P206
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ooa, PDBe:1ooa, PDBj:1ooa
PDBsum1ooa
PubMed12886018
UniProtP25799|NFKB1_MOUSE Nuclear factor NF-kappa-B p105 subunit (Gene Name=Nfkb1)

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