Structure of PDB 1oas Chain B Binding Site BS01

Receptor Information
>1oas Chain B (length=315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKIYEDNSLTIGHTPLVRLNRIGNGRILAKVESRNPSFSVKCRIGANMIW
DAEKRGVLKPGVELVEPTNGNTGIALAYVAAARGYKLTLTMPETMSIERR
KLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPANPE
IHEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLITV
AVEPTDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVGIT
NEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVILPS
SGERYLSTALFADLF
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1oas Chain B Residue 323 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1oas Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		K41 N71 V175 G176 T177 G178 T180 G228 S272 P299
Binding residue
(residue number reindexed from 1)		K41 N71 V175 G176 T177 G178 T180 G228 S272 P299
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K41 G228 S272
Catalytic site (residue number reindexed from 1) K41 G228 S272
Enzyme Commision number 2.5.1.47: cysteine synthase.
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1oas, PDBe:1oas, PDBj:1oas
PDBsum1oas
PubMed9761678
UniProtP0A1E3|CYSK_SALTY Cysteine synthase A (Gene Name=cysK)

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