Structure of PDB 1o6o Chain B Binding Site BS01

Receptor Information

>1o6o Chain B (length=439) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQ
VARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLHTLGT
ETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTL
EAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNS
LEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQY
METYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAA
EQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVC
LMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQ
LKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP

Ligand information

>1o6o Chain F (length=5) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AFSFG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1o6o Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
Resolution	2.8 Å
Binding residue (original residue number in PDB)	N171 T175 Q179 E214 F217
Binding residue (residue number reindexed from 1)	N170 T174 Q178 E213 F216

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0031267	small GTPase binding

	Biological Process
GO:0006606	protein import into nucleus
GO:0006886	intracellular protein transport

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Molecular Function

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Biological Process

External links

PDB	RCSB:1o6o, PDBe:1o6o, PDBj:1o6o
PDBsum	1o6o
PubMed	12372823
UniProt	Q14974\|IMB1_HUMAN Importin subunit beta-1 (Gene Name=KPNB1)

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