Structure of PDB 1o6e Chain B Binding Site BS01

Receptor Information

>1o6e Chain B (length=232) Species: 10376 (human gammaherpesvirus 4)

APSVYVCGFVERPDAPPKDACLHLDPLTVKSQLPLKKPLPLTVEHLPDAP
VGSVFGLYQSSAGLFSAASITSGDFLSLLDSIYHDCDIAQSQRLPLPREP
KVEALHAWLPSLSLASLHPDIPQTTADGGKLSFFDHVSICALGRRRGTTA
VYGTDLAWVLKHFSDLEPSIAAQIENDANAAKRESGCPEDHPLPLTKLIA
KAIDAGFLRNRVETLRQDRGVANIPAESYLKA

Ligand information

• Ligand ID: ISP
• InChI: InChI=1S/C3H9O4P/c1-3(2)7-8(4,5)6/h3H,1-2H3,(H2,4,5,6)
• InChIKey: QPPQHRDVPBTVEV-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: CC(C)OP(=O)(O)O
  CACTVS 3.341: CC(C)O[P](O)(O)=O
  ACDLabs 10.04: O=P(O)(O)OC(C)C
• Formula: C3 H9 O4 P
• Name: PHOSPHORYLISOPROPANE
• ChEMBL: CHEMBL144888
• DrugBank: DB03976
• ZINC: ZINC000001673625
• PDB chain: 1o6e Chain B Residue 1236

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1o6e The Crystal Structure of the Epstein-Barr Virus Protease Shows Rearrangement of the Processed C Terminus
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): S116 L117 A118 G146 R147
• Binding residue (residue number reindexed from 1): S113 L114 A115 G143 R144
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H48 S116 A118 H139 R147 R148
• Catalytic site (residue number reindexed from 1): H45 S113 A115 H136 R144 R145
• Enzyme Commision number: 3.4.21.97: assemblin.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1o6e, PDBe:1o6e, PDBj:1o6e
• PDBsum: 1o6e
• PubMed: 12421561
• UniProt: P03234|SCAF_EBVB9 Capsid scaffolding protein (Gene Name=BVRF2/BdRF1)