Structure of PDB 1nui Chain B Binding Site BS01

Receptor Information
>1nui Chain B (length=239) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFLYHIPCDNCGSSDGNSLFSDGHTFCYVCEKWKERASKRKPSGGKPGTY
NVWNFGESNGRYSALTARGISKETCQKAGYWIAKVDGVMYQVADYRDQNG
NIVSQKVRDKDKNFKTTGSHKSDALFGKHLWNGGKKIVVTEGEIDMLTVM
ELQDCKYPVVSLGHGASAAKKTCAANYEYFDQFEQIILMFDMDEAGRKAV
EEAAQVLPAGKVRVAVLPCKDANECHLNGHDREIMEQVW
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1nui Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1nui Modular Architecture of the Bacteriophage T7 Primase Couples RNA primer Synthesis to DNA Synthesis
Resolution2.9 Å
Binding residue
(original residue number in PDB)		C17 C20 C36 C39
Binding residue
(residue number reindexed from 1)		C8 C11 C27 C30
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
GO:0003896 DNA primase activity
GO:0004386 helicase activity
GO:0008270 zinc ion binding
GO:0043139 5'-3' DNA helicase activity

View graph for
Molecular Function
External links
PDB RCSB:1nui, PDBe:1nui, PDBj:1nui
PDBsum1nui
PubMed12769857
UniProtP03692|HELIC_BPT7 DNA helicase/primase (Gene Name=4)

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