Structure of PDB 1nrl Chain B Binding Site BS01

Receptor Information
>1nrl Chain B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVREEAAKWSQVRKDL
CSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIIS
FAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY
CLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGV
LQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQ
HTQRLLRIQDIHPFATPLMQELFGI
Ligand information
Receptor-Ligand Complex Structure
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PDB1nrl Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
Resolution2.0 Å
Binding residue
(original residue number in PDB)		I255 K259 I269 E270 Q272 K277 P423 L424 E427
Binding residue
(residue number reindexed from 1)		I99 K103 I113 E114 Q116 K121 P267 L268 E271
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrl, PDBe:1nrl, PDBj:1nrl
PDBsum1nrl
PubMed12909012
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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