Structure of PDB 1mzo Chain B Binding Site BS01

Receptor Information
>1mzo Chain B (length=756) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEKLATAWEGFTKGDWQNEVNVRDFIQKNYTPYEGDESFLAGATEATTTL
WDKVMEGVKLENRTHAPVDFDTAVASTITSHDAGYINKQLEKIVGLQTEA
PLKRALIPFGGIKMIEGSCKAYNRELDPMIKKIFTEYRKTHNQGVFDVYT
PDILRCRKSGVLTGLPDAYGRGRIIGDYRRVALYGIDYLMKDKLAQFTSL
QADLENGVNLEQTIRLREEIAEQHRALGQMKEMAAKYGYDISGPATNAQE
AIQWTYFGYLAAVKSQNGAAMSFGRTSTFLDVYIERDLKAGKITEQEAQE
MVDHLVMKLRMVRFLRTPEYDELFSGDPIWATESIGGMGLDGRTLVTKNS
FRFLNTLYTMGPSPEPNMTILWSEKLPLNFKKFAAKVSIDTSSLQYENDD
LMRPDFNNDDYAIACCVSPMIVGKQMQFFGARANLAKTMLYAINGGVDEK
LKMQVGPKSEPIKGDVLNYDEVMERMDHFMDWLAKQYITALNIIHYMHDK
YSYEASLMALHDRDVIRTMACGIAGLSVAADSLSAIKYAKVKPIRDEDGL
AIDFEIEGEYPQFGNNDPRVDDLAVDLVERFMKKIQKLHTYRDAIPTQSV
LTITSNVVYGKKTGNTPDGRRAGAPFGPGANPMHGRDQKGAVASLTSVAK
LPFAYAKDGISYTFSIVPNALGKDDEVRKTNLAGLMDGYFHHEASIEGGQ
HLNVNVMNREMLLDAMENPEKYPQLTIRVSGYAVRFNSLTKEQQQDVITR
TFTQSM
Ligand information
Ligand IDPYR
InChIInChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
InChIKeyLCTONWCANYUPML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC(=O)C(O)=O
OpenEye OEToolkits 1.7.6CC(=O)C(=O)O
ACDLabs 12.01O=C(C(=O)O)C
FormulaC3 H4 O3
NamePYRUVIC ACID
ChEMBLCHEMBL1162144
DrugBankDB00119
ZINCZINC000001532517
PDB chain1mzo Chain B Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1mzo Structure of Escherichia coli pyruvate formate-lyase with pyruvate.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R176 W333 C418 F432 R435 I606
Binding residue
(residue number reindexed from 1)		R173 W330 C415 F429 R432 I603
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) W333 C418 C419 G734
Catalytic site (residue number reindexed from 1) W330 C415 C416 G731
Enzyme Commision number 2.3.1.54: formate C-acetyltransferase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008861 formate C-acetyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0044814 glycolytic fermentation via PFL pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mzo, PDBe:1mzo, PDBj:1mzo
PDBsum1mzo
PubMed12454503
UniProtP09373|PFLB_ECOLI Formate acetyltransferase 1 (Gene Name=pflB)

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