Structure of PDB 1mly Chain B Binding Site BS01
Receptor Information
>1mly Chain B (length=428) Species:
562
(Escherichia coli) [
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MTTDDLAFDQRHILHPYTSMTSPLPVYPVVSAEGCELILSDGRRLVDGMS
SWWAAIHGYNHPQLNAAMKSQIDAMSHVMFGGITHAPAIELCRKLVAMTP
QPLECVFLADSGSVAVEVAMKMALQYWQAKGEARQRFLTFRNGYHGDTFG
AMSVCDPDNSMHSLWKGYLPENLFAPAPQSRMDGEWDERDMVGFARLMAA
HRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKICDREGILLIADEIATG
FGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTTREVAETISNGE
AGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQLREQLAPA
RDAEMVADVRVLGAIGVVETTHPVNMAALQKFFVEQGVWIRPFGKLIYLM
PPYIILPQQLQRLTAAVNRAVQDETFFC
Ligand information
Ligand ID
PLP
InChI
InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKey
NGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0
Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04
O=P(O)(O)OCc1cnc(c(O)c1C=O)C
Formula
C8 H10 N O6 P
Name
PYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBL
CHEMBL82202
DrugBank
DB00114
ZINC
ZINC000001532514
PDB chain
1mly Chain A Residue 730 [
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Receptor-Ligand Complex Structure
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PDB
1mly
Structural basis for the inhibition of the biosynthesis of biotin by the antibiotic amiclenomycin
Resolution
1.81 Å
Binding residue
(original residue number in PDB)
P308 T309
Binding residue
(residue number reindexed from 1)
P308 T309
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
Y17 Y144 E211 D245 A248 K274 Y398
Catalytic site (residue number reindexed from 1)
Y17 Y144 E211 D245 A248 K274 Y398
Enzyme Commision number
2.6.1.62
: adenosylmethionine--8-amino-7-oxononanoate transaminase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0004015
adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO:0008483
transaminase activity
GO:0030170
pyridoxal phosphate binding
GO:0042803
protein homodimerization activity
Biological Process
GO:0009102
biotin biosynthetic process
Cellular Component
GO:0005737
cytoplasm
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1mly
,
PDBe:1mly
,
PDBj:1mly
PDBsum
1mly
PubMed
12218056
UniProt
P12995
|BIOA_ECOLI Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (Gene Name=bioA)
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