Structure of PDB 1mdm Chain B Binding Site BS01

Receptor Information
>1mdm Chain B (length=129) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTG
DGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGK
RYVYRFVCDLQSLLGYTPEELHAMLDVKP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1mdm STRUCTURAL ANALYSIS OF THE AUTOINHIBITION OF ETS-1 AND ITS ROLE IN PROTEIN PARTNERSHIPS
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R391 R394 Y397 K404 R409
Binding residue
(residue number reindexed from 1)		R83 R86 Y89 K96 R101
Binding affinityPDBbind-CN: Kd=35pM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1mdm, PDBe:1mdm, PDBj:1mdm
PDBsum1mdm
PubMed12221090
UniProtP27577|ETS1_MOUSE Protein C-ets-1 (Gene Name=Ets1)

[Back to BioLiP]