Structure of PDB 1m0w Chain B Binding Site BS01

Receptor Information
>1m0w Chain B (length=479) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPSKDQLNELIQEVNQWAITNGLSMYPPKFEENPSNASVSPVTIYPTPIP
RKCFDEAVQIQPVFNELYARITQDMAQPDSYLHKTTEALALSDSEFTGKL
WSLYLATLKSAQYKKQNFRLGIFRSDYLIDKKKGTEQIKQVEFNTVSVSF
AGLSEKVDRLHSYLNRANKYDPKGPIYNDQNMVISDSGYLLSKALAKAVE
SYKSQQDPIVAFIVQRNERNVFDQKVLELNLLEKFGTKSVRLTFDDVNDK
LFIDDKTGKLFIRDTEQEIAVVYYRTGYTTTDYTSEKDWEARLFLEKSFA
IKAPDLLTQLSGSKKIQQLLTDEGVLGKYISDAEKKSSLLKTFVKIYPLD
DTKLGREGKRLALSEPSKYVLKPQREGNNVYKENIPNFLKGIEERHWDAY
ILMELIEPELNENNIILRDNKSYNEPIISELGIYGCVLFNDEQVLSNEFS
GSLLRSKFNTSNEGGVAAGFGCLDSIILY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1m0w Chain B Residue 1503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1m0w Large Conformational Changes in the Catalytic Cycle of Glutathione Synthase
Resolution1.8 Å
Binding residue
(original residue number in PDB)		E1146 E1386
Binding residue
(residue number reindexed from 1)		E142 E376
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R1128 E1146 N1148 S1153 K1324 K1382 E1386 R1467
Catalytic site (residue number reindexed from 1) R124 E142 N144 S149 K314 K372 E376 R455
Enzyme Commision number 6.3.2.3: glutathione synthase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004363 glutathione synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
GO:0046872 metal ion binding
Biological Process
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1m0w, PDBe:1m0w, PDBj:1m0w
PDBsum1m0w
PubMed12467574
UniProtQ08220|GSHB_YEAST Glutathione synthetase GSH2 (Gene Name=GSH2)

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