Structure of PDB 1m08 Chain B Binding Site BS01

Receptor Information
>1m08 Chain B (length=131) Species: 316407 (Escherichia coli str. K-12 substr. W3110) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRNKPGKATGKGKPVNNKWLNNAGKDLGSPVPDRIANKLRDKEFKSFDDF
RKKFWEEVSKDPELSKQFSRNNNDRMKVGKAPKTRTQDVSGKRTSFELHH
EKPISQNGGVYDMDNISVVTPKRHIDIHRGK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1m08 Chain B Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1m08 The Crystal Structure of the Nuclease Domain of Colicin E7 Suggests a Mechanism for Binding to Double-stranded DNA by the H-N-H Endonucleases
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H544 H569 H573
Binding residue
(residue number reindexed from 1)		H99 H124 H128
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) R447 R538 E542 H544 H545 H569 H573
Catalytic site (residue number reindexed from 1) R2 R93 E97 H99 H100 H124 H128
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0005102 signaling receptor binding
Biological Process
GO:0009617 response to bacterium
GO:0019835 cytolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1m08, PDBe:1m08, PDBj:1m08
PDBsum1m08
PubMed12441102
UniProtQ47112|CEA7_ECOLX Colicin-E7 (Gene Name=colE7)

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