Structure of PDB 1ltx Chain B Binding Site BS01

Receptor Information

>1ltx Chain B (length=318) Species: 10116 (Rattus norvegicus)

KDVTIKSDPDTLLLEKHADYIASYGSCMSEYLRMSGVYWGLTVMDLMGQL
HRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHV
INVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAIN
VEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSD
LLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKL
RSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVF
CMPEEVLQRVNVQPELVS

Ligand information

>1ltx Chain P (length=4)

AAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ltx Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): H190 Y241 D287 F289
• Binding residue (residue number reindexed from 1): H177 Y228 D274 F276

Enzymatic activity

• Catalytic site (original residue number in PDB): H190 R232 K235 D238 C240 Y241 D280 D287 H290
• Catalytic site (residue number reindexed from 1): H177 R219 K222 D225 C227 Y228 D267 D274 H277
• Enzyme Commision number: 2.5.1.60: protein geranylgeranyltransferase type II.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004659 prenyltransferase activity
• GO:0004661 protein geranylgeranyltransferase activity
• GO:0004663 Rab geranylgeranyltransferase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0008318 protein prenyltransferase activity
• GO:0019840 isoprenoid binding
• GO:0031267 small GTPase binding
• GO:0046872 metal ion binding

Biological Process

• GO:0018344 protein geranylgeranylation

Cellular Component

• GO:0005968 Rab-protein geranylgeranyltransferase complex

External links

• PDB: RCSB:1ltx, PDBe:1ltx, PDBj:1ltx
• PDBsum: 1ltx
• PubMed: 12620235
• UniProt: Q08603|PGTB2_RAT Geranylgeranyl transferase type-2 subunit beta (Gene Name=Rabggtb)