Structure of PDB 1lnx Chain B Binding Site BS01

Receptor Information

>1lnx Chain B (length=73) Species: 13773 (Pyrobaculum aerophilum)

CFATLGATLQDSIGKQVLVKLRDSHEIRGILRSFDQHVNLLLEDAEEIID
GNVYKRGTMVVRGENVLFISPVP

Ligand information

• Ligand ID: URI
• InChI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
• InChIKey: DRTQHJPVMGBUCF-XVFCMESISA-N
• SMILES:
  CACTVS 3.341: OC[CH]1O[CH]([CH](O)[CH]1O)N2C=CC(=O)NC2=O
  OpenEye OEToolkits 1.5.0: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
  ACDLabs 10.04: O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)CO
  OpenEye OEToolkits 1.5.0: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
  CACTVS 3.341: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
• Formula: C9 H12 N2 O6
• Name: URIDINE
• ChEMBL: CHEMBL100259
• DrugBank: DB02745
• ZINC: ZINC000002583633
• PDB chain: 1lnx Chain B Residue 8004

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1lnx The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs)
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): G13 L16 F41 Q43
• Binding residue (residue number reindexed from 1): G6 L9 F34 Q36
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome

Cellular Component

• GO:0120114 Sm-like protein family complex
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:1lnx, PDBe:1lnx, PDBj:1lnx
• PDBsum: 1lnx
• PubMed: 12649441
• UniProt: Q8ZYG5