Structure of PDB 1kzh Chain B Binding Site BS01

Receptor Information
>1kzh Chain B (length=530) Species: 139 (Borreliella burgdorferi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSLFKQERQKYIPKLPNILKKDFNNISLVYGENTEAIQDRQALKEFFKNT
YGLPIISFTEGESSLSFSKALNIGIILSGGPAPGGHNVISGVFDAIKKFN
PNSKLFGFKGGPLGLLENDKIELTESLINSYRNTGGFDIVSSGRTKIETE
EHYNKALFVAKENNLNAIIIIGGDDSNTNAAILAEYFKKNGENIQVIGVP
KTIDADLRNDHIEISFGFDSATKIYSELIGNLCRDAMSTKKYWHFVKLMG
RSASHVALECALKTHPNICIVSEEVLAKKKTLSEIIDEMVSVILKRSLNG
DNFGVVIVPEGLIEFIPEVKSLMLELCDIFIEKMKEIFVAKLSDYMKGVY
LSLPLFIQFELIKSILERVPTEKLFIEMIQSRLNDMKKRGEYKGSFTPVD
HFFGYEGRSAFPSNFDSDYCYSLGYNAVVLILNGLTGYMSCIKNLNLKPT
DWIAGGVPLTMLMNMEERYGEKKPVIKKALVDLEGRPFKEFVKNRDKWAL
NNLYLYPGPVQYFGSSEIVDEITETLKLEL
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1kzh Chain A Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1kzh The structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		T241 K243 Y244
Binding residue
(residue number reindexed from 1)		T239 K241 Y242
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) G82 G145 R146 D176 D177 K203 T204 D206 D208 R253
Catalytic site (residue number reindexed from 1) G80 G143 R144 D174 D175 K201 T202 D204 D206 R251
Enzyme Commision number 2.7.1.90: diphosphate--fructose-6-phosphate 1-phosphotransferase.
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0008443 phosphofructokinase activity
GO:0016301 kinase activity
GO:0046872 metal ion binding
GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0009749 response to glucose
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0061615 glycolytic process through fructose-6-phosphate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kzh, PDBe:1kzh, PDBj:1kzh
PDBsum1kzh
PubMed12015149
UniProtP70826|PFP_BORBU Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (Gene Name=pfp)

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