Structure of PDB 1kpl Chain B Binding Site BS01

Receptor Information
>1kpl Chain B (length=451) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIVRLRRRDQIRRLLQRDKTPLAILFMAAVVGTLTGLVGVAFEKAVSWVQ
NMRIGALVQVADHAFLLWPLAFILSALLAMVGYFLVRKFAPEAGGSGIPE
IEGALEELRPVRWWRVLPVKFIGGMGTLGAGMVLGREGPTVQIGGNLGRM
VLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYN
LISIKAVFTGVIMSSIVFRIFNGEAPIIEVGKLSDAPVNTLWLYLILGII
FGVVGPVFNSLVLRTQDMFQRFHGGEIKKWVLMGGAIGGLCGILGLIEPA
AAGGGFNLIPIAAAGNFSVGLLLFIFITRVVTTLLCFSSGAPGGIFAPML
ALGTLLGTAFGMAAAVLFPQYHLEAGTFAIAGMGALMAASVRAPLTGIVL
VLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILARTLAKQDAEQA
E
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain1kpl Chain B Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1kpl X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		S107 G355 F357
Binding residue
(residue number reindexed from 1)		S96 G344 F346
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015108 chloride transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kpl, PDBe:1kpl, PDBj:1kpl
PDBsum1kpl
PubMed11796999
UniProtQ8ZRP8|CLCA_SALTY H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

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