Structure of PDB 1kfi Chain B Binding Site BS01

Receptor Information
>1kfi Chain B (length=570) Species: 5888 (Paramecium tetraurelia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVIPAPRVQVTQPYAGQKPGTSGLRKKVSEATQPNYLENFVQSIFNTLRK
DELKPKNVLFVGGDGRYFNRQAIFSIIRLAYANDISEVHVGQAGLMSTPA
SSHYIRKVNEEVGNCIGGIILTASHNPGGKEHGDFGIKFNVRTGAPAPED
FTDQIYTHTTKIKEYLTVDYEFEKHINLDQIGVYKFEGTRLEKSHFEVKV
VDTVQDYTQLMQKLFDFDLLKGLFSNKDFSFRFDGMHGVAGPYAKHIFGT
LLGCSKESLLNCDPSEDFGGGHPDPNLTYAHDLVELLDIHKKKDVGTVPQ
FGAACDGDADRNMILGRQFFVTPSDSLAVIAANANLIFKNGLLGAARSMP
TSGALDKVAAKNGIKLFETPTGWKFFGNLMDAGLINLCGEESFGTGSNHI
REKDGIWAVLAWLTILAHKNKNTDHFVTVEEIVTQYWQQFGRNYYSRYDY
EQVDSAGANKMMEHLKTKFQYFEQLKQGNKADIYDYVDPVDQSVSKNQGV
RFVFGDGSRIIFRLSGTGSVGATIRIYFEQFEQQQIQHETATALANIIKL
GLEISDIAQFTGRNEPTVIT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1kfi Chain B Residue 700 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1kfi Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D308 D310 D312
Binding residue
(residue number reindexed from 1)		D306 D308 D310
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S126 H127 D308 D310 D312 R313 K405
Catalytic site (residue number reindexed from 1) S124 H125 D306 D308 D310 R311 K403
Enzyme Commision number 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004614 phosphoglucomutase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kfi, PDBe:1kfi, PDBj:1kfi
PDBsum1kfi
PubMed11779235
UniProtP47244|PGM1_PARTE Phosphoglucomutase-1 (Gene Name=pp63-1)

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