Structure of PDB 1jjw Chain B Binding Site BS01

Receptor Information
>1jjw Chain B (length=173) Species: 727 (Haemophilus influenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTIVSVRRNGQVVVGGDGQVSLGNTVMKGNARKVRRLYNGKVLAGFAGGT
ADAFTLFELFERKLEMHQGHLLKSAVELAKDWRTDRALRKLEAMLIVADE
KESLIITGIGDVVQPEEDQILAIGSGGNYALSAARALVENTELSAHEIVE
KSLRIAGDICVFTNTNFTIEELP
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain1jjw Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jjw Structure of Haemophilus influenzae HslV protein at 1.9 A resolution, revealing a cation-binding site near the catalytic site.
Resolution1.9 Å
Binding residue
(original residue number in PDB)
G157 D158 C160 V161 T163 N164
Binding residue
(residue number reindexed from 1)
G157 D158 C160 V161 T163 N164
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) T1 K33 G45 S125
Catalytic site (residue number reindexed from 1) T1 K33 G45 S125
Enzyme Commision number 3.4.25.2: HslU--HslV peptidase.
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0009376 HslUV protease complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1jjw, PDBe:1jjw, PDBj:1jjw
PDBsum1jjw
PubMed11717526
UniProtP43772|HSLV_HAEIN ATP-dependent protease subunit HslV (Gene Name=hslV)

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