Structure of PDB 1jiz Chain B Binding Site BS01

Receptor Information

>1jiz Chain B (length=166) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLK
FSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFD
EDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTF
RLSADDIRGIQSLYGD

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1jiz Chain B Residue 257 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1jiz Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	H119 H123 H129
Binding residue (residue number reindexed from 1)	H120 H124 H130
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H119 E120 H123 H129
Catalytic site (residue number reindexed from 1)	H120 E121 H124 H130
Enzyme Commision number	3.4.24.65: macrophage elastase.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1jiz, PDBe:1jiz, PDBj:1jiz
PDBsum	1jiz
PubMed	11575929
UniProt	P39900\|MMP12_HUMAN Macrophage metalloelastase (Gene Name=MMP12)

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