Structure of PDB 1jaz Chain B Binding Site BS01

Receptor Information
>1jaz Chain B (length=305) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPNITILATGGTIAGNAVPQLKDIANVKGEQVVNIGSQDMNDNVWLTLAK
KINTDCDKTDGFVITHGTETMEETAYFLDLTVKCDKPVVMVGAMRPSTSM
SADGPFNLYNAVVTAADKASANRGVLVVMNDTVLDGRDVTKTNTTDVATF
KSVNYGPLGYIHNGKIDYQRTPARKHTSDTPFDVSKLNELPKVGIVYNYA
NASDLPAKALVDAGYDGIVSAGVGNGNLYKSVFDTLATAAKTGTAVVRSS
RVPTGATTQDAEVDDAKYGFVASGTLNPQKARVLLQLALTQTKDPQQIQQ
IFNQY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1jaz Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jaz Crystal structure of active site mutant of antileukemic L-asparaginase reveals conserved zinc-binding site.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		D100 H197
Binding residue
(residue number reindexed from 1)		D79 H176
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T12 T89 E90 K162 E283
Catalytic site (residue number reindexed from 1) T12 T68 E69 K141 E262
Enzyme Commision number 3.5.1.1: asparaginase.
Gene Ontology
Molecular Function
GO:0004067 asparaginase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0006528 asparagine metabolic process
GO:0006530 asparagine catabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0032991 protein-containing complex
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jaz, PDBe:1jaz, PDBj:1jaz
PDBsum1jaz
PubMed25040257
UniProtP00805|ASPG2_ECOLI L-asparaginase 2 (Gene Name=ansB)

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