Structure of PDB 1j37 Chain B Binding Site BS01

Receptor Information
>1j37 Chain B (length=598) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IQAKEYLENLNKELAKRTNVETEAAWAYRSAITDENEKKKNEISAELAKF
MKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSA
MESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDK
AGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFA
DIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIAD
IVSPFPEKPLVDVSAEMEKQAYTPLKMFQMGDDFFTSMNLTKLPQDFWDK
SIIEKPTDGRDLVCHASAWDFYLIDDVRIKQCTRVTQDQLFTVHHELGHI
QYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVR
DDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKL
RDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSAC
IKAGQYDPDNVELPLDNCDIYGSARAGAAFHNMLSMGASKPWPDALEAFN
GERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWITSNKCVSSHHHHH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1j37 Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1j37 Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H367 H371 E395
Binding residue
(residue number reindexed from 1)		H345 H349 E373
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H337 A338 H367 E368 H371 E395 H497 Y507
Catalytic site (residue number reindexed from 1) H315 A316 H345 E346 H349 E373 H475 Y485
Enzyme Commision number 3.4.15.1: peptidyl-dipeptidase A.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1j37, PDBe:1j37, PDBj:1j37
PDBsum1j37
PubMed12633854
UniProtQ10714|ACE_DROME Angiotensin-converting enzyme (Gene Name=Ance)

[Back to BioLiP]