Structure of PDB 1iyx Chain B Binding Site BS01

Receptor Information

>1iyx Chain B (length=431) Species: 1354 (Enterococcus hirae)

SIITDVYAREILDSRGNPTIEVEVYTESGAFGRGMVPSGASTGEYEAVEL
RDGDKARYGGKGVTKAVDNVNNIIAEAIIGYDVRDQMAIDKAMIALDGTP
NKGKLGANAILGVSIAVARAAADYLEVPLYHYLGGFNTKVLPTPMMNIIN
GGSHADNSIDFQEFMIMPVGAPTFKEALRMGAEVFHALAAILKSRGLATS
VGDEGGFAPNLGSNEEGFEVIIEAIEKAGYVPGKDVVLAMDAASSEFYDK
EKGVYVLADSGEGEKTTDEMIKFYEELVSKYPIISIEDGLDENDWDGFKK
LTDVLGDKVQLVGDDLFVTNTQKLSEGIEKGIANSILIKVNQIGTLTETF
EAIEMAKEAGYTAVVSHRSGETEDSTISDIAVATNAGQIKTGSLSRTDRI
AKYNQLLRIEDQLGEVAEYKGLKSFYNLKAA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1iyx Chain B Residue 1432

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1iyx Crystal Structure of Enterococcus hirae Enolase at 2.8 A Resolution
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): D241 D314
• Binding residue (residue number reindexed from 1): D241 D314
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): S41 H154 E163 E204 D241 E287 D314 K339 H367 K390
• Catalytic site (residue number reindexed from 1): S41 H154 E163 E204 D241 E287 D314 K339 H367 K390
• Enzyme Commision number: 4.2.1.11: phosphopyruvate hydratase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004634 phosphopyruvate hydratase activity
• GO:0016829 lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006096 glycolytic process

Cellular Component

• GO:0000015 phosphopyruvate hydratase complex
• GO:0005576 extracellular region
• GO:0005737 cytoplasm
• GO:0009986 cell surface

External links

• PDB: RCSB:1iyx, PDBe:1iyx, PDBj:1iyx
• PDBsum: 1iyx
• PubMed: 12869539
• UniProt: Q8GR70|ENO_ENTHR Enolase (Gene Name=eno)