Structure of PDB 1im8 Chain B Binding Site BS01

Receptor Information
>1im8 Chain B (length=223) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDENVAEVFPDMIQRSVPGYSNIITAIGMLAERFVTADSNVYDLGCSRGA
ATLSARRNINQPNVKIIGIDNSQPMVERCRQHIAAYHSEIPVEILCNDIR
HVEIKNASMVILNFTLQFLPPEDRIALLTKIYEGLNPNGVLVLSEKFRFE
DTKINHLLIDLHHQFKRANGYSELEVSQKRTALENVMRTDSIETHKVRLK
NVGFSQVELWFQCFNFGSMIAVK
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain1im8 Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1im8 Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F136 R198
Binding residue
(residue number reindexed from 1)		F118 R180
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.3.-
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0002098 tRNA wobble uridine modification

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Molecular Function
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Biological Process
External links
PDB RCSB:1im8, PDBe:1im8, PDBj:1im8
PDBsum1im8
PubMed11746687
UniProtP43985|CMOA_HAEIN Carboxy-S-adenosyl-L-methionine synthase (Gene Name=cmoA)

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