Structure of PDB 1hy7 Chain B Binding Site BS01

Receptor Information

>1hy7 Chain B (length=171) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF
SRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDD
DEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYLTDLTRFRL
SQDDINGIQSLYGPPPDSPET

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1hy7 Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1hy7 Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Resolution	1.5 Å
Binding residue (original residue number in PDB)	H701 H705 H711
Binding residue (residue number reindexed from 1)	H119 H123 H129
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H701 E702 H705 H711
Catalytic site (residue number reindexed from 1)	H119 E120 H123 H129
Enzyme Commision number	3.4.24.17: stromelysin 1.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1hy7, PDBe:1hy7, PDBj:1hy7
PDBsum	1hy7
PubMed	11297453
UniProt	P08254\|MMP3_HUMAN Stromelysin-1 (Gene Name=MMP3)

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