Structure of PDB 1hy0 Chain B Binding Site BS01

Receptor Information
>1hy0 Chain B (length=448) Species: 8839 (Anas platyrhynchos) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPIMQMLSTSISTEQRLSEVDIQASIAYAKALEKAGILTKTELEKILSGL
EKISEELSKGVIVVTQSDEDIQTANERRLKELIGDIAGKLHTGRSRNEQV
VTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYTHLQKAQPI
RWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAGNPLDIDREMLR
SELEFASISLNSMDAISERDFVVEFLSVATLLLIHLSKMAEDLIIYSTSE
FGFLTLSDAFSTGSSLMPQKKNPDSLELIRSKSGRVFGRLASILMVLKGL
PSTYNKDLQEDKEAVIDVVDTLTAVLQVATGVISTLQISKENMEKALTPE
MLATDLALYLVRKGMPFRQAHTASGKAVHLAETKGIAINNLTLEDLKSIS
PLFSSDVSQVFNFVNSVEQYTALGGTAKSSVTTQIEQLRELMKKQKEQ
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1hy0 Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1hy0 Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S281 M284 K287
Binding residue
(residue number reindexed from 1)		S264 M267 K270
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E86 T159 H160 S281 S282 K287 E294
Catalytic site (residue number reindexed from 1) E69 T142 H143 S264 S265 K270 E277
Enzyme Commision number 4.3.2.1: argininosuccinate lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity
GO:0005212 structural constituent of eye lens
Biological Process
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hy0, PDBe:1hy0, PDBj:1hy0
PDBsum1hy0
PubMed11258884
UniProtP24057|ARLY1_ANAPL Delta-1 crystallin (Gene Name=ASL1)

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