Structure of PDB 1hxr Chain B Binding Site BS01

Receptor Information
>1hxr Chain B (length=115) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLFLPSMRKKPDLVDGS
NPDGDVLEEHWLVNDMFIFENVGFTKDVGNVKFLVCADCEIGPIGWHCLD
DKNSFYVALERVSHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1hxr Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1hxr A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		C23 C26 C94 C97
Binding residue
(residue number reindexed from 1)		C15 C18 C86 C89
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007264 small GTPase-mediated signal transduction
GO:0015031 protein transport
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hxr, PDBe:1hxr, PDBj:1hxr
PDBsum1hxr
PubMed11258916
UniProtQ08326|MSS4_RAT Guanine nucleotide exchange factor MSS4 (Gene Name=Rabif)

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