Structure of PDB 1hr8 Chain B Binding Site BS01

Receptor Information
>1hr8 Chain B (length=439) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLQ
HLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAV
DILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEITYKD
QPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHEKLVQ
YAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIAIALE
GVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSLANSY
MSFSTSYADSGLWGMYIVTDSNEHNVRLIVNEILKEWKRIKSGKISDAEV
NRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVDKITK
DDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ
Ligand information
>1hr8 Chain O (length=13) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SIRFFKPATRTLC
Receptor-Ligand Complex Structure
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PDB1hr8 Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Q73 F77 N100 A101 Y102 T103 S104 E160 I180 L181 L286 A290 N294 S327 Q379
Binding residue
(residue number reindexed from 1)		Q50 F54 N77 A78 Y79 T80 S81 E137 I157 L158 L263 A267 N271 S304 Q356
Enzymatic activity
Catalytic site (original residue number in PDB) H70 Q73 H74 E143 E150
Catalytic site (residue number reindexed from 1) H47 Q50 H51 E120 E127
Enzyme Commision number 3.4.24.64: mitochondrial processing peptidase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006627 protein processing involved in protein targeting to mitochondrion
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0017087 mitochondrial processing peptidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hr8, PDBe:1hr8, PDBj:1hr8
PDBsum1hr8
PubMed11470436
UniProtP10507|MPPB_YEAST Mitochondrial-processing peptidase subunit beta (Gene Name=MAS1)

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