Structure of PDB 1h7u Chain B Binding Site BS01

Receptor Information

>1h7u Chain B (length=301) Species: 9606 (Homo sapiens)

VLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFE
GLTLEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRG
TTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTN
QLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEE
YGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCR
LVNEVYHMYNRHQYPFVVLNISVDSECVDILLQEEKLLLAVLKTSLIGMF
D

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1h7u Chain A Residue 1365

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1h7u Structure and Function of the N-Terminal 40 kDa Fragment of Human Pms2: A Monomeric Ghl ATPase
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): F363 D364
• Binding residue (residue number reindexed from 1): F300 D301
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0030983 mismatched DNA binding
• GO:0140664 ATP-dependent DNA damage sensor activity

Biological Process

• GO:0006298 mismatch repair

Cellular Component

• GO:0032300 mismatch repair complex

External links

• PDB: RCSB:1h7u, PDBe:1h7u, PDBj:1h7u
• PDBsum: 1h7u
• PubMed: 11574484
• UniProt: P54278|PMS2_HUMAN Mismatch repair endonuclease PMS2 (Gene Name=PMS2)